| S4631 |
Prochlorperazine dimaleate salt |
Prochlorperazine dimaleate (Prochlorperazin, Compazine, Capazine, Stemetil) is a dopamine (D2) receptor antagonist. |
Selective |
|
| S6853 |
ONC206 |
ONC206 is a selective antagonist of DRD2/3/4 with broad-spectrum anti-tumor activity. |
Selective |
|
| S5714 |
lurasidone |
Lurasidone (SM-13496) is a second-generation antipsychotic agent that exhibits full antagonism at dopamine D2 and serotonin 5-HT2A receptors with binding affinities Ki = 1 nM and Ki = 0.5 nM, respectively. It also has high affinity for serotonin 5-HT7 receptors (Ki = 0.5 nM), partial agonist activity at 5-HT1A receptors (Ki = 6.4 nM) and lacks affinity for histamine H1 and muscarinic M1 receptors. |
Selective |
D2 receptor, Ki: 1 nM |
| S3201 |
Trifluoperazine 2HCl |
Trifluoperazine (NSC-17474, RP-7623, SKF-5019) 2HCl is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM. Trifluoperazine also inhibits calmodulin (CaM). |
Selective |
Dopamine D2 receptor, IC50: 1.1 nM |
| S5185 |
Perospirone |
Perospirone (SM-9018 free base) is an orally active antagonist of 5-hydroxytryptamine2 (5-HT2) receptor, dopamine2 (D2) receptor and 5-HT1A receptor with Ki of 0.6 nM, 1.4 nM and 2.9 nM, respectively. |
Selective |
D2 receptor, Ki: 1.4 nM |
| S4889 |
Perospirone hydrochloride |
Perospirone (SM-9018) is an atypical or second-generation antipsychotic of the azapirone family that antagonizes serotonin 5HT2A receptors and dopamine D2 receptors. It also displays affinity towards 5HT1A receptors as a partial agonist. |
Selective |
D2 receptor, Ki: 1.4 nM |
| S3044 |
Lurasidone HCl |
Lurasidone (SM-13496) is an atypical antipsychotic, inhibits Dopamine D2, 5-HT2A, 5-HT7, 5-HT1A and noradrenaline α2C with IC50 of 1.68 nM, 2.03 nM, 0.495 nM, 6.75 nM and 10.8 nM, respectively. |
Selective |
D2 receptor, IC50: 1.68 nM |
| S0104 |
Pardoprunox (SLV-308) hydrochloride |
Pardoprunox hydrochloride (DU-126891, SME-308) is a potent but partial dopamine D2 receptor agonist with pEC50 of 8.0, and a partial agonist in the induction of [35S]GTPγS binding with pEC50 of 9.2 and a serotonin 5-HT1A receptor agonist, with pEC50 of 6.3, respectively. |
Selective |
D2 receptor, pEC50: 8.0 |
| S3189 |
Ropinirole HCl |
Ropinirole (SKF-101468A) a selective dopamine D2 receptors agonist with Ki of 29 nM. |
Selective |
D2 receptor, Ki: 29 nM |
| S5153 |
Tetrahydroberberine |
Tetrahydroberberine (Canadine) is an isoquinoline alkaloid with micromolar affinity for dopamine D2 (antagonist, pKi = 6.08) and 5-HT1A (agonist, pKi = 5.38) receptors but moderate to no affinity for other relevant serotonin receptors. |
Selective |
D2 receptor, pKi: 6.08 |
| S4251 |
Phenothiazine |
Phenothiazine (ENT 38) is a dopamine-2 (D2) receptor antagonist therefore decreases the effect of dopamine in the brain. |
Selective |
|
| S4655 |
Sulpiride |
Sulpiride (Dolmatil, Dobren, Sulpyrid, Aiglonyl, Dogmatil) is a dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. |
Selective |
|
| S2493 |
Olanzapine |
Olanzapine (LY170053,Zyprexa, Zalasta, Zolafren, Olzapin, Oferta, Zypadhera) is a high affinity for 5-HT2 serotonin and D2 dopamine receptor antagonist. |
Selective |
|
| S2461 |
Domperidone |
Domperidone is an oral dopamine D2 receptor antagonist, used to treat nausea and vomiting. |
Selective |
|
| S4289 |
Metoclopramide HCl |
Metoclopramide HCl(Metoclopramide hydrochloride) is a selective dopamine D2 receptor antagonist, used for the treatment of nausea and vomiting.
|
Selective |
|
| S2104 |
Levosulpiride |
Levosulpiride(RV-12309,S-(-)-Sulpiride) is a selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent. |
Selective |
|
| S5481 |
Molindone hydrochloride |
Molindone hydrochloride is the hydrochloride salt form of molindone, a conventional antipsychotic used in the therapy of schizophrenia. It is a dopamine D2/D5 receptor antagonist. |
Pan |
|
| S5842 |
Cabergoline |
Cabergoline (FCE-21336), an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. |
Pan |
D2 receptor, IC50: 0.7 nM |
| S2460 |
Pramipexole |
Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively. |
Pan |
D2S Receptor, Ki: 3.9 nM; D2L Receptor, Ki: 2.2 nM |
| S5066 |
Pramipexole dihydrochloride |
Pramipexole dihydrochloride (SND919) is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS) with Ki values of 3.9 nM, 2.2 nM, 0.5 nM and 5.1 nM for D2S receptor, D2L receptor, D3 receptor and D4 receptor. |
Pan |
D2S Receptor, Ki: 3.9 nM; D2L Receptor, Ki: 2.2 nM |
| S1771 |
Chlorprothixene |
Chlorprothixene(Minithixen,Truxal) has strong binding affinities to dopamine and histamine receptors, such as D1, D2, D3, D5, H1, 5-HT2, 5-HT6 and 5-HT7, with Ki of 18 nM, 2.96 nM, 4.56 nM, 9 nM, 3.75 nM, 9.4 nM, 3 nM and 5.6 nM, respectively. |
Pan |
D2 receptor, Ki: 2.96 nM |
| S4358 |
Pimozide |
Pimozide (Orap, R6238) is an antagonist of Dopamine Receptors with Ki of 0.83 nM, 3.0 nM and 6600 nM for dopamine D3, D2 and D1 receptors, respectively. Pimozide also exhibits binding affinity at 5-HT1A and α1-adrenoceptor with Ki of 310 nM and 39 nM, respectively. Pimozide is an antipsychotic drug with anti-tumor activity and suppresses STAT3 and STAT5 activity. |
Pan |
Dopamine D2 receptor, Ki: 3.0 nM |
| S3913 |
Pimethixene maleate |
Pimethixene (Pimetixene) maleate, an antihistamine, anntimigraine agent and antiserotonergic compound, is a highly potent antagonist of a broad range of monoamine receptors, including a variety of serotonin receptors. Pimethixene maleate inhibits 5-HT2A, 5-HT2B, 5-HT2C, 5-HT1A, 5-HT1B, 5-HT6, 5-HT7, Adrenergic α-1A, Dopamine D1 Receptor, Dopamine D2 Receptor, Dopamine D4.4 Receptor, Histamine H1 Receptor, Muscarinic M1 and Muscarinic M2 with pKi of 10.22, 10.44, 8.42, 7.63, < 5, 7. |
Pan |
Dopamine D2 Receptor, pKi: 8.19 |
| S4309 |
Bromocriptine Mesylate |
Bromocriptine mesylate is a dopamine receptor agonist with a Ki of 12.2 nM for D3 receptor and D2 receptor and a Ki of 1659 nM, 59.7 nM, 1691 nM for D1 receptor, D4 receptor, and D5 receptor, respectively. Bromocriptine mesylate is used in the treatment of Parkinson's disease, hyperprolactinemia-associated dysfunctions, and acromegaly. |
Pan |
D2 receptor, Ki: 12.2 nM |
| S4086 |
Loxapine Succinate |
Loxapine Succinate(NSC 759578) is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent. |
Pan |
D2 receptor (Human), Ki: 24 nM; D2 receptor (human), Ki: 24 nM; D2 receptor (bovine), Ki: 26 nM |
| S3656 |
Piribedil |
Piribedil (Trivastal, Trivastan) is a relatively selective dopamine (D2/D3) agonist with moderate antidepressant activity. It also has α2-adrenergic (α2A/α2C) antagonist properties. |
Pan |
D2 receptor, pKi: 6.9 |
| S2437 |
Rotundine |
Rotundine (L-tetrahydropalmatine, L-THP) is a selective dopamine D1 receptor antagonist with IC50 of 166 nM. |
Pan |
D2 receptor, IC50: 1.47 μM |
| S2011 |
Pramipexole 2HCl Monohydrate |
Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease. |
Pan |
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